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ICSN3250 hydrochloride
CAS No. 1561902-79-1
ICSN3250 hydrochloride ( ICSN-3250 )
产品货号. M12224 CAS No. 1561902-79-1
ICSN3250 (ICSN-3250) 盐酸盐是一种哈利图林类似物，是一种新型特异性 mTOR 抑制剂。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 100MG | 获取报价 | 有现货 |
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| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称ICSN3250 hydrochloride
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述ICSN3250 (ICSN-3250) 盐酸盐是一种哈利图林类似物，是一种新型特异性 mTOR 抑制剂。
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产品描述ICSN3250 (ICSN-3250) hydrochloride is a halitulin-analogue that acts as a new-class, specific mTOR inhibitor through a mechanism distinct from previous mTOR inhibitors; ICSN3250 is not a kinase inhibitor of mTOR, competes with and displaces phosphatidic acid from the FRB domain in mTOR, thus preventing mTOR activation and leading to cytotoxicity; displays no inhibitory capacity towards PI3Kα, β, γ, or δ; inhibits mTORC1 by following an unprecedented mechanism that involved its competition with PA at the FRB domain of mTOR to overcome the TSC negative regulation of mTORC1; ICSN3250 specifically targets cancer cells both in vitro and ex vivo.
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体外实验——
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体内实验——
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同义词ICSN-3250
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通路PI3K/Akt/mTOR signaling
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靶点mTOR
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受体mTOR
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研究领域——
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适应症——
化学信息
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CAS Number1561902-79-1
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分子量633.139
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分子式C31H41ClN4O8
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纯度>98% (HPLC)
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溶解度——
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SMILESC1CCCCCCN(CCCCC1)CCCN2C=C(C(=C2)C3=CC(=C(C(=C3)O)O)[N+](=O)[O-])C4=CC(=C(C(=C4)O)O)[N+](=O)[O-].Cl
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化学全称5,5'-(1-(3-(azacyclotridecan-1-yl)propyl)-1H-pyrrole-3,4-diyl)bis(3-nitrobenzene-1,2-diol) hydrochloride
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Nguyen TL, et al. Cancer Res. 2018 Jul 27. pii: canres.0232.2018.
